The Peripherin Polyclonal Antibody (CAB4048) is a valuable tool designed for researchers investigating peripherin, a type III intermediate filament protein found predominantly in the peripheral nervous system. This antibody, produced using a polyclonal antibody design, exhibits high reactivity with human samples and is validated for use in various applications including Western blot and immunohistochemistry.Peripherin is known to play a critical role in the formation and maintenance of neuronal cytoskeleton, particularly in peripheral sensory neurons. Its expression has been linked to various neurological disorders and nerve injury, making it an important target for studies in neuroscience and neurology.
By utilizing the Peripherin Polyclonal Antibody, researchers can detect and analyze peripherin expression in different cell types, providing valuable insights into its functions and potential implications in disease pathology.Furthermore, understanding the role of peripherin may lead to the development of novel therapeutic strategies for treating neurodegenerative diseases, nerve damage, and other conditions affecting the peripheral nervous system. By studying the expression and regulation of peripherin, researchers can uncover new pathways for intervention and improve our understanding of the mechanisms underlying these disorders.
Product Name:
PRPH Rabbit Polyclonal Antibody
SKU:
CAB4048
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PRPH (NP_006253.2).
This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis.
Purification Method:
Affinity purification
Gene ID:
5630
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PRPH antibody (CAB4048) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
