The PRPF6 polyclonal antibody (CAB17122) is a valuable tool for research involving the PRPF6 protein, a key player in RNA splicing and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PRPF6 protein, researchers can study its expression and function in a variety of cell types, making it an essential reagent for studies in molecular biology and genomics.
PRPF6 is essential for spliceosome assembly and pre-mRNA splicing, processes that are crucial for gene expression and cellular function. Dysregulation of PRPF6 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions. By investigating the role of PRPF6 in these conditions, researchers can gain valuable insights into disease mechanisms and potentially identify novel treatment strategies.
Product Name:
PRPF6 Rabbit Polyclonal Antibody
SKU:
CAB17122
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 592-941 of human PRPF6 (NP_036601.2).
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.
Purification Method:
Affinity purification
Gene ID:
24148
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HT-29 cells, using PRPF6 Rabbit pAb (CAB17122) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
