The PROZ Polyclonal Antibody (CAB16082) is a crucial tool for researchers studying Proz, a plasma serine protease involved in the blood coagulation cascade. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it an excellent choice for Western blotting applications. By binding to the Proz protein, this antibody enables the detection and analysis of Proz in various cell types, providing valuable insights for studies in hemostasis, thrombosis, and related disorders.Proz, also known as protein Z, serves as a key player in the coagulation pathway, contributing to the regulation of blood clot formation and prevention of excessive bleeding.
Dysregulation of Proz has been associated with thrombotic events, making it a potential target for therapeutic interventions in conditions such as venous thrombosis and cardiovascular diseases. By investigating the function and expression of Proz using this antibody, researchers can advance our understanding of coagulation processes and potentially identify new strategies for managing hemostatic disorders.
Product Name:
PROZ Rabbit Polyclonal Antibody
SKU:
CAB16082
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 220-340 of human PROZ (NP_003882.1).
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8858
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PROZ Rabbit pAb (CAB16082) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
