WNT4 Rabbit Polyclonal Antibody (CAB7809)
- SKU:
- CAB7809
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | WNT4 Rabbit Polyclonal Antibody |
SKU: | CAB7809 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 122-351 of human WNT4 (NP_110388.2). |
Sequence: | FAVT RACS SGEL EKCG CDRT VHGV SPQG FQWS GCSD NIAY GVAF SQSF VDVR ERSK GASS SRAL MNLH NNEA GRKA ILTH MRVE CKCH GVSG SCEV KTCW RAVP PFRQ VGHA LKEK FDGA TEVE PRRV GSSR ALVP RNAQ FKPH TDED LVYL EPSP DFCE QDMR SGVL GTRG RTCN KTSK AIDG CELL CCGR GFHT AQVE LAER CSCK FHWC CFVK CRQC QRLV ELHT CR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | WNT-4; SERKAL; WNT4 |
Positive Sample: | A-549,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 39kDa |
Observed MW: | 46kDa |
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
Purification Method: | Affinity purification |
Gene ID: | 54361 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |