The SSX4 Polyclonal Antibody (CAB7929) is a valuable tool for researchers studying the SSX4 protein, a member of the cancer/testis antigen family known for its role in tumorigenesis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for Western blot applications. By specifically binding to the SSX4 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in oncology and cancer research.SSX4 has been implicated in promoting tumor growth and progression, making it a promising target for developing cancer therapies and diagnostics.
Its unique expression pattern and functional significance in cancer cells make it a key focus in understanding the molecular mechanisms driving oncogenesis. Research utilizing the SSX4 Polyclonal Antibody can provide valuable insights into the role of this protein in cancer development and progression, ultimately leading to advancements in cancer treatment strategies.
Product Name:
SSX4 Rabbit Polyclonal Antibody
SKU:
CAB7929
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-188 of human SSX4 (NP_005627.1).
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
6759
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SSX4 Rabbit pAb (CAB7929) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
