The SSX2 Polyclonal Antibody (CAB6989) is a valuable tool for researchers studying the SSX2 protein, a cancer/testis antigen known to be involved in various types of cancer. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SSX2 protein, this antibody enables precise detection and analysis in different cell types, making it ideal for studies in oncology and cancer research.SSX2 is a member of the SSX family of proteins, which are normally expressed in the testis but can be aberrantly expressed in cancer cells, playing a role in tumorigenesis and tumor progression.
Understanding the function and regulation of SSX2 is crucial for exploring its potential as a diagnostic or therapeutic target in cancer treatment. This antibody provides researchers with a reliable tool for investigating the role of SSX2 in cancer biology, with the ultimate goal of improving treatments and outcomes for cancer patients.
Product Name:
SSX2 Rabbit Polyclonal Antibody
SKU:
CAB6989
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human SSX2 (NP_783629.1).
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X.
Purification Method:
Affinity purification
Gene ID:
6757
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using SSX2 antibody (CAB6989) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
