The Protein S100-A12 Polyclonal Antibody (CAB5328) is a valuable tool for researchers studying the S100-A12 protein, which is a member of the S100 family of calcium-binding proteins known for their involvement in inflammation and immunity. This antibody, generated in rabbits, is highly specific for detecting S100-A12 in human samples and has been validated for use in Western blot applications.S100-A12, also known as calgranulin C, is a pro-inflammatory protein that plays a role in the innate immune response by promoting the recruitment of immune cells to sites of inflammation. Elevated levels of S100-A12 have been associated with various inflammatory conditions, making it a potential biomarker for disease diagnosis and prognosis.
Furthermore, S100-A12 has been implicated in the pathogenesis of inflammatory disorders, including autoimmune diseases and inflammatory skin conditions.By using the Protein S100-A12 Polyclonal Antibody, researchers can accurately detect and quantify S100-A12 protein levels in different cell types and tissues, providing valuable insights into the role of this protein in immune responses and inflammatory diseases. This antibody is an essential tool for advancing our understanding of S100-A12 biology and its potential as a therapeutic target for the treatment of inflammatory disorders.
Product Name:
S100A12 Rabbit Polyclonal Antibody
SKU:
CAB5328
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human S100A12 (NP_005612.1).
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.
Purification Method:
Affinity purification
Gene ID:
6283
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293F cells transfected with S100A12 using S100A12 Rabbit pAb (CAB5328) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
