The Quaking Polyclonal Antibody (CAB7043) is a vital tool for researchers studying the Quaking protein, an RNA-binding protein crucial for myelination in the central nervous system. This antibody, produced in rabbits, displays high reactivity with human samples and has been extensively validated for Western blot applications.The Quaking protein is involved in regulating myelination in the CNS, making it a key player in processes like oligodendrocyte differentiation and myelin formation. Dysregulation of Quaking has been linked to neurological disorders such as multiple sclerosis and schizophrenia, highlighting its importance in neural development and function.
By targeting the Quaking protein, researchers can gain insights into the mechanisms underlying myelination and potentially develop new therapeutic strategies for treating disorders affecting the CNS. The Quaking Polyclonal Antibody offers a reliable means of detecting and analyzing Quaking protein levels in various cell types, making it an invaluable tool for researchers in the fields of neuroscience and neurology.
Product Name:
QKI Rabbit Polyclonal Antibody
SKU:
CAB7043
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human QKI (NP_006766.1).
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9444
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using QKI Rabbit pAb antibody (CAB7043) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
