The Protein MAX Polyclonal Antibody (CABP0072) is a valuable tool for researchers studying protein MAX, a key transcription factor involved in cell growth and proliferation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the protein MAX, this antibody enables researchers to detect and analyze protein levels in various cell types, making it an essential tool for studies in cancer biology and cell signaling pathways.
Protein MAX is a critical regulator of cell growth and division, with dysregulation of its activity linked to various diseases, including cancer. By understanding the role of protein MAX in cell proliferation and differentiation, researchers can gain insights into potential therapeutic targets for cancer treatment and other diseases. The Protein MAX Polyclonal Antibody is a crucial reagent for researchers aiming to elucidate the functions of protein MAX and its implications in cellular processes.
Product Name:
Phospho-MAX-S11 Rabbit Polyclonal Antibody
SKU:
CABP0072
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around S11 of human MAX (NP_002373.3).
Sequence:
VESD E
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
bHLHd4; Phospho-MAX-S11
Positive Sample:
Jurkat
Conjugate:
Unconjugated
Cellular Localization:
Cell projection, Nucleus, dendrite.
Calculated MW:
18kDa
Observed MW:
21kDa
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4149
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using Phospho-MAX-S11 Rabbit pAb (CABP0072) at 1:1000 dilution. Jurkat cells were treated by serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
