The Jumonji Polyclonal Antibody (CAB9823) is a valuable tool for research involving the Jumonji protein, a key player in epigenetic regulatory processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the Jumonji protein, researchers can detect and analyze its expression in various cell types, making it an essential tool for studies in epigenetics, gene regulation, and cancer research.The Jumonji protein, part of the JmjC-domain-containing protein family, functions as a histone demethylase, controlling gene expression by modifying chromatin structure.
Its involvement in epigenetic regulation makes it an attractive target for investigations into developmental processes, cellular differentiation, and disease mechanisms. Understanding the role of Jumonji in these pathways is essential for developing targeted therapies and advancing our knowledge of gene regulation and epigenetic modifications.
Product Name:
JARID2 Rabbit Polyclonal Antibody
SKU:
CAB9823
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1027-1246 of human JARID2 (NP_004964.2).
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies.
Purification Method:
Affinity purification
Gene ID:
3720
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using JARID2 antibody (CAB9823) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
