The DR1 Polyclonal Antibody (CAB6903) is a valuable tool for research involving DR1, a crucial protein involved in immune response regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the DR1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.DR1, also known as immune regulatory protein, plays a vital role in maintaining immune balance by modulating inflammatory responses and suppressing immune reactions.
Its involvement in immune system modulation makes it a prime target for research on diseases such as cancer, autoimmune disorders, and chronic inflammation. Understanding the function of DR1 is key to developing therapeutic strategies that manipulate immune responses in these disease contexts.Overall, the DR1 Polyclonal Antibody (CAB6903) is an essential tool for researchers looking to delve deeper into the role of DR1 in immune regulation and its implications in various disease states.
Product Name:
DR1 Rabbit Polyclonal Antibody
SKU:
CAB6903
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1).
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Purification Method:
Affinity purification
Gene ID:
1810
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Mouse testis, using DR1 antibody (CAB6903) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
