The Cereblon Polyclonal Antibody (CAB4722) is a valuable tool for researchers studying the protein cereblon, a key player in the ubiquitin-proteasome system and a target for cancer therapeutics. Raised in rabbits, this antibody is highly specific to human samples and is validated for use in Western blot applications. By binding to cereblon, researchers can detect and analyze its expression in various cell types, making it ideal for investigations in oncology and drug development.Cereblon, a substrate receptor for the E3 ubiquitin ligase complex, is known for its role in protein degradation and cellular homeostasis.
Its involvement in cancer pathogenesis and response to targeted therapies has made it a promising target for drug discovery and personalized medicine approaches. Understanding the function of cereblon is essential for developing novel treatments and improving patient outcomes in cancer research.Overall, the Cereblon Polyclonal Antibody (CAB4722) offers researchers a reliable tool for studying the complex mechanisms involving cereblon, opening new avenues for therapeutic interventions and advancing our knowledge of cancer biology.
Product Name:
CRBN Rabbit Polyclonal Antibody
SKU:
CAB4722
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CRBN (NP_057386.2?).
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51185
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CRBN antibody (CAB4722) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
