CBFA2T2 Rabbit Polyclonal Antibody (CAB7033)
- SKU:
- CAB7033
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | CBFA2T2 Rabbit Polyclonal Antibody |
SKU: | CAB7033 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 325-604 of human CBFA2T2 (NP_005084.1). |
Sequence: | GLNG GYQD ELVD HRLT EREW ADEW KHLD HALN CIME MVEK TRRS MAVL RRCQ ESDR EELN YWKR RYNE NTEL RKTG TELV SRQH SPGS ADSL SNDS QREF NSRP GTGY VPVE FWKK TEEA VNKV KIQA MSEV QKAV AEAE QKAF EVIA TERA RMEQ TIAD VKRQ AAED AFLV INEQ EEST ENCW NCGR KASE TCSG CNIA RYCG SFCQ HKDW ERHH RLCG QNLH GQSP HGQG RPLL PVGR GSSA RSAD CSVP SPAL DKTS ATTS RSST PASV TAID TNGL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | EHT; p85; MTGR1; ZMYND3; CBFA2T2 |
Positive Sample: | Jurkat,Raji,HepG2,SW620,22Rv1,Mouse brain,Mouse testis,Mouse kidney,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 67kDa |
Observed MW: | 72kDa |
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Purification Method: | Affinity purification |
Gene ID: | 9139 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |