AGO1 Rabbit Polyclonal Antibody (CAB6022)
- SKU:
- CAB6022
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | AGO1 Rabbit Polyclonal Antibody |
SKU: | CAB6022 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human AGO1 (NP_036331.1). |
Sequence: | MEAG PSGA AAGA YLPP LQQV FQAP RRPG IGTV GKPI KLLA NYFE VDIP KIDV YHYE VDIK PDKC PRRV NREV VEYM VQHF KPQI FGDR KPVY DGKK NIYT VTAL PIGN ERVD FEVT IPGE GKDR IFKV SIKW LAIV SWRM LHEA LVSG QIPV PLES VQAL DVAM RHLA SM |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | Q99; EIF2C; hAgo1; EIF2C1; GERP95; NEDLBAS; AGO1 |
Positive Sample: | 293T,MCF7,Mouse lung,Mouse spleen,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, P-body. |
Calculated MW: | 97kDa |
Observed MW: | 100kDa |
This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon.
Purification Method: | Affinity purification |
Gene ID: | 26523 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |