The Prosaposin Polyclonal Antibody (CAB1819) is a valuable tool for researchers studying prosaposin, a multifunctional glycoprotein involved in various cellular processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to prosaposin, it enables precise detection and analysis in a range of cell types, making it ideal for investigations in neuroscience, developmental biology, and lysosomal storage disorders.Prosaposin is known for its diverse roles in cell growth, differentiation, and lysosomal enzyme activation, making it a key player in cellular homeostasis and metabolism.
Dysregulation of prosaposin has been linked to neurological disorders, lipid metabolism abnormalities, and lysosomal storage diseases. Therefore, understanding the function of prosaposin is essential for developing targeted therapies for these conditions. By utilizing the Prosaposin Polyclonal Antibody, researchers can delve deeper into the intricate mechanisms involving prosaposin and explore its potential therapeutic implications.
Product Name:
PSAP Rabbit Polyclonal Antibody
SKU:
CAB1819
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 275-524 of human PSAP (NP_002769.1).
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
5660
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSAP Rabbit pAb (CAB1819) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
