The PROP1 Polyclonal Antibody (CAB16963) is a valuable tool for researchers studying the PROP1 protein, which is involved in pituitary gland development and function. Raised in rabbits, this antibody is highly specific to human samples and is suitable for use in Western blot applications. By binding to the PROP1 protein, researchers can effectively detect and analyze its expression in various cell types, making this antibody ideal for studies in endocrinology and developmental biology.The PROP1 protein is a critical regulator of pituitary gland development and hormone production, making it a key player in the endocrine system.
Dysfunction of PROP1 has been linked to hormone deficiencies and developmental disorders, making it a promising target for research into conditions such as pituitary hypoplasia and growth hormone deficiencies. By understanding the role of PROP1, researchers can gain insights into the mechanisms underlying these disorders and potentially develop new therapeutic strategies.
Product Name:
PROP1 Rabbit Polyclonal Antibody
SKU:
CAB16963
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_006252.3).
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.
Purification Method:
Affinity purification
Gene ID:
5626
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using PROP1 Rabbit pAb (CAB16963) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 50s.
