The Proenkephalin B Polyclonal Antibody (CAB5830) is a valuable tool for researchers studying proenkephalin B, a precursor protein involved in the production of enkephalin peptides that regulate pain and stress responses. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Proenkephalin B is essential in the endogenous opioid system, playing a key role in modulating pain perception and stress responses. Dysregulation of proenkephalin B expression has been implicated in various neurological and psychiatric disorders, making it a promising target for therapeutic interventions.
By enabling the detection and analysis of proenkephalin B protein, this antibody facilitates research into the molecular mechanisms underlying pain and stress regulation. Its specificity and reliability make it an excellent choice for investigations in neuroscience, pharmacology, and related fields. Unlocking the secrets of proenkephalin B could lead to new insights into pain management and the development of novel therapeutic strategies for pain-related disorders.
Product Name:
PDYN Rabbit Polyclonal Antibody
SKU:
CAB5830
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-254 of human PDYN (NP_077722.1).
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5173
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDYN Rabbit pAb (CAB5830) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
