The PRODH Polyclonal Antibody (CAB5836) is a valuable tool for researchers studying PRODH, a critical enzyme involved in the synthesis of proline and the regulation of cellular metabolism. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in immunohistochemistry applications. By targeting the PRODH protein, this antibody enables the detection and analysis of PRODH expression in various tissues and cell types, making it an essential component for studies in metabolism, cancer, and mitochondrial function.
PRODH plays a key role in maintaining cellular redox balance and energy production, making it a potential target for therapeutic interventions in metabolic disorders and cancer. Understanding the function of PRODH is crucial for developing targeted treatments that can modulate its activity in these disease settings. The PRODH Polyclonal Antibody can help researchers uncover the role of PRODH in cellular metabolism and its implications for disease progression and treatment strategies.
Product Name:
PRODH Rabbit Polyclonal Antibody
SKU:
CAB5836
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 321-600 of human PRODH (NP_057419.4).
Mouse liver,Mouse kidney,Mouse heart,Rat liver, Rat kidney
Conjugate:
Unconjugated
Cellular Localization:
Mitochondrion matrix.
Calculated MW:
68kDa
Observed MW:
68kDa
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5625
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PRODH antibody (CAB5836) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
