Coagulation Protein C Rabbit Monoclonal Antibody (CAB4532)
The Protein C Rabbit Monoclonal Antibody (CAB4532) is a valuable tool for researchers studying Protein C, a crucial protein involved in the regulation of blood clotting and inflammation. This antibody, generated using rabbits, is highly specific and reacts strongly with human samples, making it ideal for use in various applications such as Western blotting and immunohistochemistry.Protein C plays a key role in the anticoagulant pathway, serving as a natural anticoagulant by inhibiting blood clot formation. Dysregulation of Protein C has been linked to various thrombotic disorders, making it an important target for research in hemostasis and thrombosis. By using the Protein C Rabbit Monoclonal Antibody, researchers can investigate the expression and function of Protein C in different tissues and cell types, providing valuable insights into its role in maintaining vascular health.
Furthermore, understanding the molecular mechanisms underlying Protein C function may lead to the development of novel therapeutic strategies for treating conditions associated with abnormal blood clotting, such as deep vein thrombosis and pulmonary embolism. The Protein C Rabbit Monoclonal Antibody is a reliable tool for exploring the intricate biology of Protein C and its implications for cardiovascular health and thrombotic disorders.
Product Name:
Coagulation Protein C Rabbit Monoclonal Antibody
SKU:
CAB4532
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-461 of human Coagulation Coagulation Protein C (P04070).
PC; APC; PROC1; THPH3; THPH4; Coagulation Protein C
Positive Sample:
HT-29,Mouse liver
Conjugate:
Unconjugated
Cellular Localization:
Endoplasmic reticulum, Golgi apparatus, Secreted.
Calculated MW:
52kDa
Observed MW:
52kDa
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Purification Method:
Affinity purification
Gene ID:
5624
Clone Number:
ARC1023
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Coagulation Coagulation Protein C Rabbit mAb (CAB4532) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
