The ProBetaCellulin Polyclonal Antibody (CAB2588) is a cutting-edge tool for researchers investigating ProBetaCellulin, a protein involved in beta-cell development and survival. This antibody, produced using rabbits, displays high specificity towards human samples and is validated for use in techniques such as Western blot. By targeting the ProBetaCellulin protein, researchers can accurately detect and study its expression in various cell types, making it an essential asset for studies in diabetes and pancreatic biology.
ProBetaCellulin is a key player in regulating beta-cell function, impacting insulin production and glucose homeostasis. Dysregulation of this protein has been implicated in conditions such as type 1 and type 2 diabetes, making it a promising target for therapeutic interventions. Understanding the mechanisms by which ProBetaCellulin influences beta-cell health is vital for developing strategies to protect and restore beta-cell function in diabetes and related disorders.
Product Name:
BTC Rabbit Polyclonal Antibody
SKU:
CAB2588
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 32-178 of human BTC (NP_001720.1).
Cell membrane, Secreted, Single-pass type I membrane protein, extracellular space.
Calculated MW:
20kDa
Observed MW:
20kDa
This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.
Purification Method:
Affinity purification
Gene ID:
685
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BTC Rabbit pAb (CAB2588) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
