The Pro-Neuropeptide Y Polyclonal Antibody (CAB3178) is a valuable tool for researchers studying neuropeptide Y, a neurotransmitter involved in a variety of physiological processes such as appetite regulation, stress response, and cardiovascular function. This antibody is raised in rabbits and is highly specific for human samples, making it ideal for use in experiments focusing on human tissues.Neuropeptide Y is known to play a role in modulating the activity of neurons in the brain and peripheral nervous system, and abnormalities in its signaling have been implicated in various disorders including obesity, anxiety, and cardiovascular disease.
The Pro-Neuropeptide Y Polyclonal Antibody binds specifically to the neuropeptide Y molecule, allowing for precise detection and analysis in a variety of cell types.By using this antibody in Western blot applications, researchers can gain valuable insights into the expression and regulation of neuropeptide Y in different physiological and pathological conditions. Understanding the intricate mechanisms of neuropeptide Y signaling is crucial for developing potential therapeutic interventions for conditions related to its dysregulation.
Product Name:
NPY Rabbit Polyclonal Antibody
SKU:
CAB3178
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-97 of NPY (NP_000896.1).
Sequence:
YPSK PDNP GEDA PAED MARY YSAL RHYI NLIT RQRY GKRS SPET LISD LLMR ESTE NVPR TRLE DPAM W
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.
Purification Method:
Affinity purification
Gene ID:
4852
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using NPY Rabbit pAb (CAB3178) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
