NPY Rabbit Polyclonal Antibody (CAB3178)
- SKU:
- CAB3178
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | NPY Rabbit Polyclonal Antibody |
SKU: | CAB3178 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-97 of NPY (NP_000896.1). |
Sequence: | YPSK PDNP GEDA PAED MARY YSAL RHYI NLIT RQRY GKRS SPET LISD LLMR ESTE NVPR TRLE DPAM W |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | PYY4; NPY |
Positive Sample: | SH-SY5Y |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 11kDa |
Observed MW: | 11kDa |
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.
Purification Method: | Affinity purification |
Gene ID: | 4852 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |