The Pro-MCH Polyclonal Antibody (CAB6692) is a valuable tool for researchers studying the Pro-Melanin-Concentrating Hormone (Pro-MCH) protein, involved in the regulation of various physiological processes including energy homeostasis and stress response. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Pro-MCH is a precursor to the MCH neuropeptide, known for its roles in regulating feeding behavior, energy balance, and sleep patterns. Research suggests potential links between MCH dysregulation and metabolic disorders like obesity and diabetes, making it a promising target for therapeutic interventions.
By specifically binding to the Pro-MCH protein, this antibody enables precise detection and analysis in a variety of cell types, making it suitable for studies in neuroscience, endocrinology, and metabolism research. Understanding the functions and mechanisms of Pro-MCH could lead to insights into various physiological and pathological conditions, paving the way for novel treatment approaches in metabolic disorders and other related fields.
Product Name:
PMCH Rabbit Polyclonal Antibody
SKU:
CAB6692
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-165 of human PMCH (NP_002665.2).
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5.
Purification Method:
Affinity purification
Gene ID:
5367
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PMCH antibody (CAB6692) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
