The Pro-Cathepsin H Polyclonal Antibody (CAB5368) is a valuable tool for researchers studying cathepsin H, a lysosomal cysteine protease involved in various physiological processes including antigen processing, tumor invasion, and metastasis. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blotting and immunohistochemistry applications.Cathepsin H is a key enzyme in the lysosomal degradation pathway, playing a crucial role in the regulation of protein turnover and cellular homeostasis. Dysregulation of cathepsin H has been implicated in several disease conditions, including cancer, neurodegenerative disorders, and inflammatory diseases.
By utilizing the Pro-Cathepsin H Polyclonal Antibody, researchers can unravel the intricate mechanisms underlying cathepsin H function, paving the way for potential therapeutic interventions targeting this protease.Overall, the Pro-Cathepsin H Polyclonal Antibody (CAB5368) serves as a valuable tool for investigating the physiological and pathological roles of cathepsin H, providing crucial insights into its involvement in disease progression and offering potential targets for therapeutic development.
Product Name:
CTSH Rabbit Polyclonal Antibody
SKU:
CAB5368
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-140 of human CTSH (NP_004381.2).
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
1512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CTSH antibody (CAB5368) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
