The PRMT9 Polyclonal Antibody (CAB10491) is a valuable tool for research involving PRMT9, a protein arginine methyltransferase with important functions in cellular processes such as gene expression regulation and RNA processing. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is suitable for use in Western blot applications. By targeting the PRMT9 protein, researchers can effectively study its expression levels and localization in various cell types, providing insights into its role in cellular pathways and diseases.
PRMT9 is known for its involvement in post-translational modification of proteins through arginine methylation, impacting processes like protein-protein interactions and signal transduction. Dysfunction of PRMT9 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. By studying the function of PRMT9 using this antibody, researchers can gain valuable knowledge that may lead to the development of new treatment strategies for these conditions.
Product Name:
PRMT9 Rabbit Polyclonal Antibody
SKU:
CAB10491
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human PRMT9 (NP_612373.2).
This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
90826
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PRMT9 antibody (CAB10491) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
