The PRMT8 Polyclonal Antibody (CAB18440) is a valuable tool for researchers studying PRMT8, a protein involved in a variety of cellular processes, including gene regulation, signaling, and protein function. This antibody, produced in rabbits, exhibits high specificity for PRMT8 and is validated for use in Western blot applications. By targeting the PRMT8 protein, researchers can easily detect and analyze PRMT8 expression in different cell types, providing insights into its function and role in various biological pathways.PRMT8 is a member of the protein arginine methyltransferase (PRMT) family, known for its ability to modify arginine residues in proteins, thereby influencing their activity and function.
Studies have shown that PRMT8 plays a role in neuronal development, synaptic plasticity, and neurodegenerative diseases, making it a promising target for research in neuroscience and neurobiology. Understanding the mechanisms underlying PRMT8 activity could lead to the development of novel therapeutic strategies for neurological disorders and conditions affecting the central nervous system.Overall, the PRMT8 Polyclonal Antibody is a powerful tool for investigating the function of PRMT8 in physiological and pathological conditions, offering valuable insights into its potential as a therapeutic target in neurobiology and beyond.
Product Name:
[KO Validated] PRMT8 Rabbit Polyclonal Antibody
SKU:
CAB18440
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human PRMT8 (NP_062828.3).
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).
Purification Method:
Affinity purification
Gene ID:
56341
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and PRMT8 knockout (KO) 293T cells, using [KO Validated] PRMT8 Rabbit pAb (CAB18440) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
