PRMT6 Rabbit Monoclonal Antibody (CAB5085)
- SKU:
- CAB5085
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HRMT1L6
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | PRMT6 Rabbit Monoclonal Antibody |
SKU: | CAB5085 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PRMT6 (Q96LA8). |
Sequence: | MLEW RLGF WSQV KQHY GVDM SCLE GFAT RCLM GHSE IVVQ GLSG EDVL ARPQ RFAQ LELS RAGL EQEL EAGV GGRF RCSC YGSA PMHG FAIW FQVT FPGG E |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | HRMT1L6; PRMT6 |
Positive Sample: | HeLa,MCF7,NIH/3T3,Jurkat,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 42kDa |
Observed MW: | 42kDa |
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
Purification Method: | Affinity purification |
Gene ID: | 55170 |
Clone Number: | ARC1277 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |