PRMT6 Polyclonal Antibody (CAB2318)
- SKU:
- CAB2318
Description
| Product Name: | PRMT6 Polyclonal Antibody |
| SKU: | CAB2318 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-375 of human PRMT6 (NP_060607.2). |
| Sequence: | MSQP KKRK LESG GGGE GGEG TEEE DGAE REAA LERP RRTK RERD QLYY ECYS DVSV HEEM IADR VRTD AYRL GILR NWAA LRGK TVLD VGAG TGIL SIFC AQAG ARRV YAVE ASAI WQQA REVV RFNG LEDR VHVL PGPV ETVE LPEQ VDAI VSEW MGYG LLHE SMLS SVLH ARTK WLKE GGLL LPAS AELF IAPI SDQM LEWR LGFW SQVK QHYG VDMS CLEG FATR CLMG HSEI VVQG LSGE DVLA RPQR FAQL ELSR AGLE QELE AGVG GRFR CSCY GSAP MHGF AIWF QVTF PGGE SEKP LVLS TSPF HPAT HWKQ ALLY LNEP VQVE QDTD VSGE ITLL PSRD NPRR LRVL LRYK VGDQ EEKT KDFA MED |
| Tested Applications: | WB IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
| Synonyms: | HRMT1L6; PRMT6 |
| Positive Sample: | NCI-H460,293T,HeLa,Jurkat,MCF7,K-562 |
| Conjugate: | Unconjugated |
| Cellular Localization: | Nucleus. |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
| Purification Method: | Affinity purification |
| Gene ID: | 55170 |
| Storage Buffer: | Store at -20℃ Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using PRMT6 Rabbit pAb (CAB2318) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s. |
Related Products
PRMT6 Rabbit Monoclonal Antibody (CAB5085)
