The PRMT5 Polyclonal Antibody (CAB1520) is a valuable tool for research involving PRMT5, a protein responsible for arginine methylation and implicated in various cellular processes, including gene expression regulation and cell signaling. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blotting and other applications. By binding specifically to PRMT5, this antibody allows for the detection and analysis of the protein in different cell types, making it ideal for studies in epigenetics, cancer biology, and cellular signaling pathways.
PRMT5 is a key player in the epigenetic regulation of gene expression and is known to be dysregulated in various cancers and other diseases. Understanding the functions and mechanisms of PRMT5 is crucial for the development of targeted therapies aimed at disrupting its activity in cancer cells or modulating its functions in other disease contexts. The PRMT5 Polyclonal Antibody offers researchers a reliable tool for investigating the role of PRMT5 in cellular processes and disease pathways.
Product Name:
PRMT5 Rabbit Polyclonal Antibody
SKU:
CAB1520
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PRMT5 (NP_006100.2).
This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10419
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PRMT5 Rabbit pAb (CAB1520) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
