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PRKD1/PRKD2/PRKD3 Antibody (PACO04738)

SKU:
PACO04738
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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PRKD1/PRKD2/PRKD3 Antibody (PACO04738)

The PRKD1/PRKD2/PRKD3 Antibody (PACO04738) is a valuable tool for researchers studying the PRKD family of proteins, which are involved in various cellular processes including cell growth, differentiation, and survival. This antibody, produced in rabbits, is highly specific and reacts with human samples, making it a reliable tool for Western blot applications. The PRKD family, consisting of PRKD1, PRKD2, and PRKD3, plays crucial roles in signal transduction pathways and is implicated in diseases such as cancer and cardiovascular disorders.

Understanding the functions and regulation of PRKD proteins can provide insights into disease mechanisms and potentially identify new therapeutic targets.With its high reactivity and specificity, the PRKD1/PRKD2/PRKD3 Antibody (PACO04738) is an essential tool for researchers investigating the roles of PRKD proteins in cellular processes and disease pathogenesis. Its use can lead to breakthroughs in drug development and personalized medicine approaches targeting the PRKD signaling pathway.

Antibody Name:PRKD1/PRKD2/PRKD3 Antibody
Antibody SKU:PACO04738
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human PKD1/2/3 around the non-phosphorylation site of S738/S742.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PRKD1; PKD; PKD1; PRKCM; Serine/threonine-protein kinase D1; Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu; PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2; PRKD3; EPK2; PRKCN; Serine/threonine-protein kinas
UniProt Protein Function:PRKD1: a CAMK kinase of the PKD family. Cleavage by caspase-3 following DNA damage activates it and alters its subcellular localization. Sensitizes cells to apoptosis induced by genotoxic stress. Its cleavage is blocked in cells that over-express the anti-apoptotic Bcl-x(L) protein. Expression of a caspase-resistant mutant partially inhibits DNA damage-induced apoptosis. Its activation by TLR ligands is dependent on MyD88, IRAK4 and -1, but not TRAF6. Essential for MyD88-dependent proinflammatory immune responses. Activated by diacylglycerol and phorbol esters. Binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Colocalizes with F-actin at peripheral F-actin-rich structures in membrane ruffles at the edge of lamellipodia in cervical carcinoma cells. Substrates reportedly include critical regulatory proteins including CREB, SSH1L, CTNNB1, HDACs 5 and 7, PKD1, HPK1, MARK2, PIP5K2A, PPP1R14A
UniProt Protein Details:

Protein type:EC 2.7.11.13; Protein kinase, CAMK; Motility/polarity/chemotaxis; Autophagy; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; PKD family

Chromosomal Location of Human Ortholog: 14q11

Cellular Component: cytoplasm; cytosol; Golgi apparatus; integral to plasma membrane; plasma membrane; trans-Golgi network

Molecular Function:identical protein binding; kinase activity; protein binding; protein kinase C activity; protein serine/threonine kinase activity

Biological Process: activation of CREB transcription factor; activation of NF-kappaB transcription factor; cell proliferation; Golgi organization and biogenesis; Golgi vesicle transport; integrin-mediated signaling pathway; negative regulation of endocytosis; peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; Ras protein signal transduction; regulation of protein stability; signal transduction; sphingolipid biosynthetic process; vascular endothelial growth factor receptor signaling pathway

NCBI Summary:PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]
UniProt Code:Q15139
NCBI GenInfo Identifier:209572639
NCBI Gene ID:5587
NCBI Accession:Q15139.2
UniProt Secondary Accession:Q15139,A6NL64, B2RAF6,
UniProt Related Accession:Q15139
Molecular Weight:101,704 Da
NCBI Full Name:Serine/threonine-protein kinase D1
NCBI Synonym Full Names:protein kinase D1
NCBI Official Symbol:PRKD1  
NCBI Official Synonym Symbols:PKD; PKCM; PRKCM; PKC-MU  
NCBI Protein Information:serine/threonine-protein kinase D1
UniProt Protein Name:Serine/threonine-protein kinase D1
UniProt Synonym Protein Names:Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:PRKD1  
UniProt Entry Name:KPCD1_HUMAN

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