The PRKCZ Polyclonal Antibody (CAB14178) is a versatile tool for researchers studying PRKCZ, a crucial protein involved in cell signaling pathways and various cellular processes. The antibody, generated in rabbits, exhibits high specificity and sensitivity for PRKCZ in human samples, making it ideal for Western blot applications. By targeting the PRKCZ protein, this antibody enables precise detection and analysis in a wide range of cell types, offering valuable insights into its role in signaling cascades and disease pathways.PRKCZ, also known as protein kinase C zeta, is a key player in regulating cell proliferation, differentiation, and survival, with implications in cancer, inflammatory diseases, and neurological disorders.
By investigating the function and interactions of PRKCZ, researchers can uncover potential therapeutic targets for treating these conditions. The PRKCZ Polyclonal Antibody is a reliable tool for advancing research in fields such as oncology, immunology, and neuroscience, facilitating the exploration of PRKCZ biology and its therapeutic potential.
Product Name:
PKC zeta Rabbit Polyclonal Antibody
SKU:
CAB14178
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 476-547 of human PKC zeta (NP_002735.3).
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
5590
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PKC zeta Rabbit pAb (CAB14178) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
