The PRKCQ Polyclonal Antibody (CAB5834) is a valuable tool for researchers studying the protein kinase C theta (PRKCQ) molecule, which plays a crucial role in immune cell signaling and regulation. This antibody, produced in rabbits, has been extensively validated for Western blot applications and is highly reactive with human samples. By specifically binding to PRKCQ, this antibody allows for the detection and analysis of PRKCQ in various cell types, making it ideal for studies in immunology and cancer research.
PRKCQ is known for its involvement in T cell activation and differentiation, making it a key player in the immune response to pathogens and diseases. Dysregulation of PRKCQ signaling has been linked to various autoimmune disorders and cancers, highlighting the importance of studying this molecule in disease pathogenesis. By understanding the role of PRKCQ, researchers may uncover new therapeutic targets for treating immune-related conditions and developing more effective cancer therapies.
Product Name:
PRKCQ Rabbit Polyclonal Antibody
SKU:
CAB5834
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PRKCQ (NP_006248.1).
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Purification Method:
Affinity purification
Gene ID:
5588
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PRKCQ Antibody (CAB5834) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
