PRKCI Rabbit Polyclonal Antibody (CAB18348)
- SKU:
- CAB18348
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | PRKCI Rabbit Polyclonal Antibody |
SKU: | CAB18348 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-596 of human PRKCI (P41743). |
Sequence: | MPTQ RDSS TMSH TVAG GGSG DHSH QVRV KAYY RGDI MITH FEPS ISFE GLCN EVRD MCSF DNEQ LFTM KWID EEGD PCTV SSQL ELEE AFRL YELN KDSE LLIH VFPC VPER PGMP CPGE DKSI YRRG ARRW RKLY CANG HTFQ AKRF NRRA HCAI CTDR IWGL GRQG YKCI NCKL LVHK KCHK LVTI ECGR HSLP QEPV MPMD QSSM HSDH AQTV IPYN PSSH ESLD QVGE EKEA MNTR ESGK ASSS LGLQ DFDL LRVI GRGS YAKV LLVR LKKT DRIY AMKV VKKE LVND DEDI DWVQ TEKH VFEQ ASNH PFLV GLHS CFQT ESRL FFVI EYVN GGDL MFHM QRQR KLPE EHAR FYSA EISL ALNY LHER GIIY RDLK LDNV LLDS EGHI KLTD YGMC KEGL RPGD TTST FCGT PNYI APEI LRGE DYGF SVDW WALG VLMF EMMA GRSP FDIV GSSD NPDQ NTED YLFQ VILE KQIR IPRS LSVK AASV LKSF LNKD PKER LGCH PQTG FADI QGHP FFRN VDWD MMEQ KQVV PPFK PNIS GEFG LDNF DSQF TNEP VQLT PDDD DIVR KIDQ SEFE GFEY INPL LMSA EECV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PKCI; DXS1179E; nPKC-iota; PRKCI |
Positive Sample: | U-251MG,Mouse brain,Rat brain |
Cellular Localization: | Cytoplasm, Endosome, Membrane, Nucleus. |
Calculated MW: | 68kDa |
Observed MW: | 68kDa |
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
Purification Method: | Affinity purification |
Gene ID: | 5584 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |