PKC gamma Rabbit Polyclonal Antibody (CAB7922)
- SKU:
- CAB7922
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PKC gamma Rabbit Polyclonal Antibody |
SKU: | CAB7922 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 558-697 of human PKC gamma (NP_002730.1). |
Sequence: | EDEE ELFQ AIME QTVT YPKS LSRE AVAI CKGF LTKH PGKR LGSG PDGE PTIR AHGF FRWI DWER LERL EIPP PFRP RPCG RSGE NFDK FFTR AAPA LTPP DRLV LASI DQAD FQGF TYVN PDFV HPDA RSPT SPVP VPVM |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PKCC; PKCG; SCA14; PKCI(3); PKCgamma; PKC-gamma; PKC gamma |
Positive Sample: | THP-1,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Peripheral membrane protein, dendrite, perinuclear region, synapse, synaptosome. |
Calculated MW: | 78kDa |
Observed MW: | 78kDa |
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5582 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |