PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ/PRKCZ Antibody (PACO06761)
- SKU:
- PACO06761
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ/PRKCZ Antibody (PACO06761)
The PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ Polyclonal Antibody (PACO06761) is a versatile tool for researchers interested in studying protein kinase C isoforms. This antibody, produced in rabbits, is highly specific to these isoforms and has been validated for use in various applications including Western blot and immunohistochemistry.Protein kinase C (PKC) isoforms play key roles in a wide range of cellular processes, including cell growth, differentiation, and apoptosis. The PRK family of proteins are involved in various signaling pathways and have been implicated in diseases such as cancer, diabetes, and neurological disorders.
Understanding the function of specific PKC isoforms is essential for unraveling their role in disease pathogenesis and for developing targeted therapies.The PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ Polyclonal Antibody enables reliable detection and analysis of these important signaling molecules in different cell types and tissues. Its high specificity and sensitivity make it an invaluable tool for researchers investigating the function of PKC isoforms in health and disease.
| Antibody Name: | PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ/PRKCZ Antibody (PACO06761) |
| Antibody SKU: | PACO06761 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:5000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human PKC around the non-phosphorylation site of T497. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of MCF-7 cells using PKC Polyclonal Antibody. |
 | Western Blot analysis of MCF-7 cells using PKC Polyclonal Antibody. |
| Synonyms: | PRKCA; PKCA; PRKACA; Protein kinase C α type; PKC-A; PKC-α; PRKCB; PKCB; PRKCB1; Protein kinase C β type; PKC-B; PKC-β; PRKCD; Protein kinase C delta type; Tyrosine-protein kinase PRKCD; nPKC-delta; PRKCE; PKCE; Protein kinase |
| UniProt Protein Function: | PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators. |
| UniProt Protein Details: | Protein type:EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Oncoprotein; Kinase, protein; Protein kinase, AGC; AGC group; PKC family; Alpha subfamily Chromosomal Location of Human Ortholog: 17q22-q23.2 Cellular Component: nucleoplasm; photoreceptor outer segment; mitochondrion; cell soma; endoplasmic reticulum; perinuclear region of cytoplasm; apical part of cell; mitochondrial membrane; dendrite; cytoplasm; plasma membrane; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; enzyme binding; protein kinase C activity; zinc ion binding; calcium-dependent protein kinase C activity; ATP binding; protein kinase activity Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; nerve growth factor receptor signaling pathway; regulation of muscle contraction; mitotic nuclear envelope disassembly; positive regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of insulin receptor signaling pathway; signal transduction; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; induction of positive chemotaxis; synaptic transmission; negative regulation of cell proliferation; chondrocyte differentiation; angiogenesis; cell adhesion; positive regulation of macrophage differentiation; regulation of peptidyl-tyrosine phosphorylation; regulation of the force of heart contraction; inactivation of MAPK activity; epidermal growth factor receptor signaling pathway; platelet activation; neutrophil chemotaxis; fibroblast growth factor receptor signaling pathway; positive regulation of blood vessel endothelial cell migration; adenylate cyclase activation; negative regulation of adenylate cyclase activity; cellular calcium ion homeostasis; rhodopsin mediated signaling; negative regulation of glucose import; positive regulation of angiogenesis; regulation of rhodopsin mediated signaling; phospholipase C activation; energy reserve metabolic process; innate immune response; gene expression; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion; positive regulation of cell migration; positive regulation of inflammatory response |
| NCBI Summary: | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17252 |
| NCBI GenInfo Identifier: | 317373571 |
| NCBI Gene ID: | 5578 |
| NCBI Accession: | P17252.4 |
| UniProt Secondary Accession: | P17252,Q15137, Q32M72, Q96RE4, B5BU22, |
| UniProt Related Accession: | P17252 |
| Molecular Weight: | 76,750 Da |
| NCBI Full Name: | Protein kinase C alpha type |
| NCBI Synonym Full Names: | protein kinase C, alpha |
| NCBI Official Symbol: | PRKCAÂ Â |
| NCBI Official Synonym Symbols: | AAG6; PKCA; PRKACA; PKC-alpha  |
| NCBI Protein Information: | protein kinase C alpha type; PKC-A; aging-associated gene 6 |
| UniProt Protein Name: | Protein kinase C alpha type |
| Protein Family: | Protein kinase |
| UniProt Gene Name: | PRKCAÂ Â |
| UniProt Entry Name: | KPCA_HUMAN |
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