The PRKCA Polyclonal Antibody (CAB13342) is a specialized tool for researchers studying PRKCA, a protein kinase C involved in various cellular processes, including cell growth, differentiation, and apoptosis. This antibody is produced in rabbits and specifically targets human samples, with validated use in Western blot applications.PRKCA, also known as protein kinase C alpha, is a key regulator of signal transduction pathways involved in cell proliferation and survival. Dysregulation of PRKCA has been linked to numerous diseases, including cancer and neurological disorders.
By utilizing the PRKCA Polyclonal Antibody, researchers can detect and analyze PRKCA levels in a variety of cell types, providing valuable insights into its role in disease progression and potential therapeutic targets.The PRKCA Polyclonal Antibody is a valuable tool for scientists conducting research in cell biology, cancer biology, and drug development. With its high reactivity and specificity, this antibody opens doors for exploring the molecular mechanisms underlying PRKCA function and its implications in disease pathology.
Product Name:
PKC alpha Rabbit Polyclonal Antibody
SKU:
CAB13342
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 573-672 of human PKC alpha (NP_002728.2).
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
Purification Method:
Affinity purification
Gene ID:
5578
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PKC alpha Rabbit pAb (CAB13342) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
