The PRKCA Polyclonal Antibody (CAB0267) is a valuable tool for researchers studying PRKCA, a protein kinase C enzyme that plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Raised in rabbits, this antibody has been validated for use in Western blot applications and is highly reactive with human samples.PRKCA, also known as protein kinase C alpha, is involved in the regulation of cell signaling pathways and is implicated in diseases such as cancer, Alzheimer's, and heart disease. By targeting PRKCA, researchers can gain insights into the role of this enzyme in disease progression and potentially develop targeted therapies.
This polyclonal antibody binds specifically to the PRKCA protein, allowing for accurate detection and analysis in a variety of cell types. Its versatility and reliability make it an ideal choice for studies in cell biology, cancer research, and drug development. By understanding the functions of PRKCA, researchers can uncover new insights into disease mechanisms and identify novel therapeutic targets for future treatments.
Product Name:
PKC alpha Rabbit Polyclonal Antibody
SKU:
CAB0267
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 573-672 of human PKC alpha (NP_002728.2).
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
Purification Method:
Affinity purification
Gene ID:
5578
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using PKC alpha Rabbit pAb (CAB0267) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
