PRKAG3 Rabbit Polyclonal Antibody (CAB14132)
- SKU:
- CAB14132
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | PRKAG3 Rabbit Polyclonal Antibody |
SKU: | CAB14132 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human PRKAG3 (NP_059127.2). |
Sequence: | MEPG LEHA LRRT PSWS SLGG SEHQ EMSF LEQE NSSS WPSP AVTS SSER IRGK RRAK ALRW TRQK SVEE GE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | AMPKG3; SMGMQTL; PRKAG3 |
Positive Sample: | Mouse brain,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, extracellular space, nucleoplasm, nucleus |
Calculated MW: | 54kDa |
Observed MW: | 54kDa |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.
Purification Method: | Affinity purification |
Gene ID: | 53632 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |