PRKAG1/PRKAG2/PRKAG3 Antibody (PACO03303)
- SKU:
- PACO03303
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PRKAG1/PRKAG2/PRKAG3 Antibody (PACO03303)
The PRKAG1/PRKAG2/PRKAG3 Polyclonal Antibody (PACO03303) is a valuable tool for researchers studying the PRKAG family of proteins. These proteins play a crucial role in energy sensing and metabolic regulation, making them important targets in understanding diseases such as diabetes, heart disease, and cancer.Raised in rabbits, this antibody is highly specific and sensitive to human samples, making it ideal for Western blot applications. It binds to all three PRKAG proteins, allowing for the detection and analysis of these key regulators in various cell types.
This antibody is essential for studies focused on metabolic pathways, energy balance, and cellular signaling related to PRKAG proteins.The PRKAG1/PRKAG2/PRKAG3 Polyclonal Antibody (PACO03303) provides researchers with a powerful tool to investigate the role of the PRKAG family in health and disease. Its high reactivity and specificity make it a reliable choice for immunology and metabolic research, offering insights that may lead to the development of novel therapeutic strategies in the future.
| Antibody Name: | PRKAG1/PRKAG2/PRKAG3 Antibody |
| Antibody SKU: | PACO03303 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human AMPKgamma1/2/3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK subunit gamma-1; AMPKg; PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2; AMPK gamma2; AMPK subunit gamma-2; H91620p; PRKAG3; AMPKG3; 5'-AMP-activated protein |
| UniProt Protein Function: | AMPKG1: a non-catalytic subunit of AMPK, a highly conserved kinase of the CAMKL family. The holoenzyme consists of a catalytic subunit (alpha) and two regulatory subunits (beta, gamma). Each subunit exists as multiple genetic isoforms giving rise to 12 different possible combinations of holoenzyme. Plays a key role in regulation of energy homeostasis. Activated by an elevated AMP-ATP ratio due to environmental stress, such as heat shock, hypoxia and ischemia. AMPK phosphorylates and regulates many metabolic enzymes. |
| UniProt Protein Details: | Protein type:Autophagy; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 12q12-q14 Cellular Component: AMP-activated protein kinase complex; cytosol; membrane; nucleoplasm Molecular Function:ADP binding; AMP binding; AMP-activated protein kinase activity; ATP binding; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase regulator activity; protein binding; protein kinase activity; protein kinase binding Biological Process: cell cycle arrest; macroautophagy; positive regulation of protein kinase activity; protein amino acid phosphorylation; regulation of glycolysis; signal transduction; spermatogenesis |
| NCBI Summary: | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P54619 |
| NCBI GenInfo Identifier: | 1703037 |
| NCBI Gene ID: | 5571 |
| NCBI Accession: | P54619.1 |
| UniProt Secondary Accession: | P54619,Q8N7V9, B4DDT7, |
| UniProt Related Accession: | P54619 |
| Molecular Weight: | 38,533 Da |
| NCBI Full Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
| NCBI Synonym Full Names: | protein kinase AMP-activated non-catalytic subunit gamma 1 |
| NCBI Official Symbol: | PRKAG1Â Â |
| NCBI Official Synonym Symbols: | AMPKGÂ Â |
| NCBI Protein Information: | 5'-AMP-activated protein kinase subunit gamma-1 |
| UniProt Protein Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
| Protein Family: | 5'-AMP-activated protein kinase |
| UniProt Gene Name: | PRKAG1Â Â |
| UniProt Entry Name: | AAKG1_HUMAN |
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