PRKACA/PRKACB Antibody (PACO06759)
- SKU:
- PACO06759
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PRKACA/PRKACB Antibody (PACO06759)
The PRKACA/PRKACB Polyclonal Antibody (PACO06759) is a valuable tool for researchers studying PRKACA and PRKACB, two key proteins involved in various cellular processes. This antibody, raised in rabbits, shows high reactivity with human samples and has been validated for Western blot applications.PRKACA and PRKACB are protein kinase A catalytic subunits that play essential roles in signaling pathways related to cell growth, metabolism, and gene expression. Their dysregulation has been linked to a variety of diseases, including cancer and metabolic disorders.
By targeting these proteins with the PRKACA/PRKACB Polyclonal Antibody, researchers can investigate their expression and activity in different cell types, providing valuable insights into their functions and potential therapeutic applications.Overall, the PRKACA/PRKACB Polyclonal Antibody is a reliable tool for studying the roles of PRKACA and PRKACB in cellular signaling, making it a valuable asset for research in areas such as cancer biology, metabolism, and drug development.
| Antibody Name: | PRKACA/PRKACB Antibody (PACO06759) |
| Antibody SKU: | PACO06759 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the N-terminal region of human PKA α / β cat. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of K562 cells using PKA alpha / beta cat Polyclonal Antibody. |
 | Western Blot analysis of Jurkat cells using PKAalpha / beta cat Polyclonal Antibody. |
| Synonyms: | PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit α; PKA C-α; PRKACB; cAMP-dependent protein kinase catalytic subunit β; PKA C-β |
| UniProt Protein Function: | PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.11; AGC group; PKA family Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: centrosome; membrane; mitochondrion; plasma membrane; cytosol; nucleus; neuromuscular junction; AMP-activated protein kinase complex; cAMP-dependent protein kinase complex Molecular Function:protein binding; cAMP-dependent protein kinase activity; ubiquitin protein ligase binding; protein serine/threonine/tyrosine kinase activity; protein kinase binding; ATP binding Biological Process: nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; water transport; pathogenesis; signal transduction; protein amino acid phosphorylation; positive regulation of protein export from nucleus; triacylglycerol catabolic process; G2/M transition of mitotic cell cycle; transmembrane transport; sperm capacitation; regulation of synaptic transmission; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytosolic calcium ion homeostasis; regulation of osteoblast differentiation; regulation of heart rate; organelle organization and biogenesis; activation of protein kinase A; peptidyl-threonine phosphorylation; glucose metabolic process; gluconeogenesis; peptidyl-serine phosphorylation; mesoderm formation; phospholipase C activation; regulation of protein binding; neural tube closure; carbohydrate metabolic process; energy reserve metabolic process; innate immune response; renal water homeostasis; mitotic cell cycle; blood coagulation; regulation of insulin secretion |
| NCBI Summary: | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17612 |
| NCBI GenInfo Identifier: | 125205 |
| NCBI Gene ID: | 5566 |
| NCBI Accession: | P17612.2 |
| UniProt Secondary Accession: | P17612,Q32P54, Q9H2Y0, Q9NRB4, Q9NRH9, |
| UniProt Related Accession: | P17612 |
| Molecular Weight: | 39,953 Da |
| NCBI Full Name: | cAMP-dependent protein kinase catalytic subunit alpha |
| NCBI Synonym Full Names: | protein kinase, cAMP-dependent, catalytic, alpha |
| NCBI Official Symbol: | PRKACAÂ Â |
| NCBI Official Synonym Symbols: | PKACAÂ Â |
| NCBI Protein Information: | cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; protein kinase A catalytic subunit; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1 |
| UniProt Protein Name: | cAMP-dependent protein kinase catalytic subunit alpha |
| Protein Family: | cAMP-dependent protein kinase |
| UniProt Gene Name: | PRKACAÂ Â |
| UniProt Entry Name: | KAPCA_HUMAN |
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