PRKAB2 Rabbit Polyclonal Antibody (CAB6952)
- SKU:
- CAB6952
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | PRKAB2 Rabbit Polyclonal Antibody |
SKU: | CAB6952 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human PRKAB2 (NP_005390.1). |
Sequence: | MGNT TSDR VSGE RHGA KAAR SEGA GGHA PGKE HKIM VGST DDPS VFSL PDSK LPGD KEFV SWQQ DLED SVKP TQQA RPTV IRWS EGGK EVFI SGSF NNWS TKIP LIKS HNDF VAIL DLPE GEHQ YKFF VDGQ WVHD PSEP VVTS QLGT INNL IHVK KSDF EVFD ALKL DSME SSET SCRD LSSS PPGP YGQE MYAF RSEE RFKS PPIL PPHL LQVI LNKD TNIS CDPA LLPE PNHV MLNH LYAL SIKD SVMV LSAT HRYK KKYV TTLL YKPI |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | PRKAB2 |
Positive Sample: | Jurkat,Mouse brain,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nucleoplasm, nucleus |
Calculated MW: | 30kDa |
Observed MW: | 33kDa |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5565 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |