AMPKβ1 Rabbit Polyclonal Antibody (CAB7921)
- SKU:
- CAB7921
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | AMPKβ1 Rabbit Polyclonal Antibody |
SKU: | CAB7921 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human AMPKβ1 (NP_006244.2). |
Sequence: | WSKL PLTR SHNN FVAI LDLP EGEH QYKF FVDG QWTH DPSE PIVT SQLG TVNN IIQV KKTD FEVF DALM VDSQ KCSD VSEL SSSP PGPY HQEP YVCK PEER F |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | AMPK; HAMPKb; AMPKβ1 |
Positive Sample: | A-431,MCF7,Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nucleoplasm, nucleus |
Calculated MW: | 30kDa |
Observed MW: | 37kDa |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Purification Method: | Affinity purification |
Gene ID: | 5564 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |