The PRKAB1 Polyclonal Antibody (CAB7921) is a valuable tool for researchers studying PRKAB1, a key regulatory subunit of the AMP-activated protein kinase (AMPK) complex. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the PRKAB1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in metabolic research and energy homeostasis.PRKAB1 is a crucial component in the regulation of cellular energy levels and metabolism, making it a target of interest in investigations related to diabetes, obesity, and metabolic disorders.
By understanding the role of PRKAB1 in AMPK activity, researchers can gain insights into how cellular energy balance is maintained and potentially develop novel therapeutic strategies for metabolic diseases.Overall, the PRKAB1 Polyclonal Antibody (CAB7921) offers researchers a reliable tool for studying the function and regulation of PRKAB1, contributing to advances in the field of metabolic research and potentially paving the way for the development of new treatments for metabolic disorders.
Product Name:
AMPKβ1 Rabbit Polyclonal Antibody
SKU:
CAB7921
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human AMPKβ1 (NP_006244.2).
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Purification Method:
Affinity purification
Gene ID:
5564
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using AMPKβ1 Rabbit pAb (CAB7921) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
