Prion Protein Rabbit Monoclonal Antibody (CAB8821)
- SKU:
- CAB8821
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | Prion Protein Rabbit Monoclonal Antibody |
SKU: | CAB8821 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 154-253 of human Prion Protein (P04156). |
Sequence: | MHRY PNQV YYRP MDEY SNQN NFVH DCVN ITIK QHTV TTTT KGEN FTET DVKM MERV VEQM CITQ YERE SQAY YQRG SSMV LFSS PPVI LLIS FLIF LIVG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; Prion Protein |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, GPI-anchor, Golgi apparatus, Lipid-anchor, Nucleus. |
Calculated MW: | 28kDa |
Observed MW: | 30kDa |
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5621 |
Clone Number: | ARC1315 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |