The Prion Protein Polyclonal Antibody is a valuable tool for researchers studying the prion protein, a crucial molecule involved in neurodegenerative diseases such as Creutzfeldt-Jakob disease. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the prion protein, this antibody allows for the detection and analysis of this important protein in various cell types.The prion protein, also known as PrP, is known for its role in the development of prion diseases, which are characterized by the misfolding and aggregation of the prion protein in the brain.
Research on the prion protein is essential for understanding the mechanisms underlying these devastating diseases and developing potential therapeutic interventions.With its high specificity and sensitivity, the Prion Protein Polyclonal Antibody is an essential tool for researchers investigating the prion protein and its implications in neurodegenerative disorders. By enabling the study of prion protein expression and function, this antibody contributes to advancements in the field of neuroscience and the quest to unravel the mysteries of prion diseases.
Product Name:
Prion Protein Polyclonal Antibody
SKU:
CAB21570
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-230 of human Prion Protein (NP_001073592.1).
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5621
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using Prion Protein Rabbit pAb (CAB21570) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
