PRG2 Polyclonal Antibody (CAB24855)
- SKU:
- CAB24855
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IF
Description
Product Name: | PRG2 Polyclonal Antibody |
SKU: | CAB24855 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-222 of human PRG2(NP_002719.3). |
Sequence: | LHLR SETS TFET PLGA KTLP EDEE TPEQ EMEE TPCR ELEE EEEW GSGS EDAS KKDG AVES ISVP DMVD KNLT CPEE EDTV KVVG IPGC QTCR YLLV RSLQ TFSQ AWFT CRRC YRGN LVSI HNFN INYR IQCS VSAL NQGQ VWIG GRIT GSGR CRRF QWVD GSRW NFAY WAAH QPWS RGGH CVAL CTRG GHWR RAHC LRRL PFIC SY |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | PRG2; BMPG; MBP; MBP1; proMBP; bone marrow proteoglycan |
Positive Sample: | THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, Secreted, secretory vesicle. |
Calculated MW: | 23kDa/25kDa |
Observed MW: | 28kDa |
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5553 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |