The PRG2 Polyclonal Antibody is a powerful tool for researchers studying the PRG2 protein, which is involved in inflammatory responses and immune regulation. PRG2, also known as Cloron, is a secreted protein that plays a role in the modulation of inflammation and allergic reactions.This antibody is raised in rabbits and has been validated for use in various applications, including Western blotting. It specifically binds to the PRG2 protein, allowing for accurate detection and analysis in a variety of cell types.
This makes it an ideal choice for studies in immunology, inflammation, and allergy research.The PRG2 Polyclonal Antibody is particularly valuable for investigating diseases characterized by dysregulated immune responses, such as asthma, autoimmune disorders, and chronic inflammatory conditions. By understanding the function of PRG2, researchers can develop targeted therapies to modulate inflammatory pathways and potentially treat these conditions effectively.
Product Name:
PRG2 Polyclonal Antibody
SKU:
CAB24855
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-222 of human PRG2(NP_002719.3).
PRG2; BMPG; MBP; MBP1; proMBP; bone marrow proteoglycan
Positive Sample:
THP-1
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasmic vesicle, Secreted, secretory vesicle.
Calculated MW:
23kDa/25kDa
Observed MW:
28kDa
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5553
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells using PRG2 Rabbit pAb(CAB24855) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:45s.
