The PRG2 Polyclonal Antibody (CAB2532) is a valuable tool for researchers studying the PRG2 protein, which plays a critical role in immune regulation and inflammation. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding specifically to the PRG2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential asset for studies in immunology and inflammatory conditions.
PRG2, also known as eosinophil major basic protein (MBP), is involved in modulating immune responses and is associated with allergic reactions and inflammatory disorders. Understanding the function of PRG2 is key to developing targeted therapies for conditions such as asthma, allergies, and inflammatory diseases. The PRG2 Polyclonal Antibody provides researchers with a reliable tool to advance their understanding of PRG2 and its role in immune regulation and disease pathogenesis.
Product Name:
PRG2 Rabbit Polyclonal Antibody
SKU:
CAB2532
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PRG2 (NP_002719.3).
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5553
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using PRG2 Rabbit pAb (CAB2532) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
