Perforin Rabbit Polyclonal Antibody (CAB0093)
- SKU:
- CAB0093
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Perforin Rabbit Polyclonal Antibody |
SKU: | CAB0093 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human Perforin (NP_005032.2). |
Sequence: | EEKK KKHK MTAS FHQT YRER HSEV VGGH HTSI NDLL FGIQ AGPE QYSA WVNS LPGS PGLV DYTL EPLH VLLD SQDP RREA LRRA LSQY LTDR ARWR DCSR PCPP GRQK SPRD PCQC VCHG SAVT TQDC CPRQ RGLA QLEV TFIQ AWGL WGDW FTAT DAYV KLFF GGQE LRTS TVWD NNNP IWSV RLDF GDVL LATG GPLR LQVW DQDS GRDD DLLG TCDQ APKS GSHE VRCN LNHG HLKF RYHA RCLP HLGG GTCL DYVP QMLL GEPP GNRS GAVW |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | P1; PFP; HPLH2; Perforin |
Positive Sample: | Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic granule lumen, Endosome lumen, Multi-pass membrane protein, Secreted. |
Calculated MW: | 61kDa |
Observed MW: | 70kDa/61kDa |
This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.
Purification Method: | Affinity purification |
Gene ID: | 5551 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |