Anti-PREX1 Antibody (CAB18344)
- SKU:
- CAB18344
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-PREX1 Antibody (CAB18344)
The PREX1 Polyclonal Antibody (CAB18344) is a versatile tool for researchers studying the PREX1 protein, a key regulator of cell growth and migration. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in Western blot applications. By specifically binding to the PREX1 protein, this antibody allows for the detection and analysis of PREX1 in a variety of cell types, making it an essential tool for studies in cell biology, cancer research, and drug development.
PREX1 is a phosphatidylinositol-3,4,5-trisphosphate-dependent Rac guanine nucleotide exchange factor, involved in signaling pathways that regulate cell proliferation, survival, and migration. Dysregulation of PREX1 has been linked to various diseases, including cancer, making it a promising target for therapeutic intervention. By investigating the function of PREX1, researchers can gain insights into the mechanisms underlying disease progression and potentially identify novel treatment strategies.
| Antibody Name: | Anti-PREX1 Antibody |
| Antibody SKU: | CAB18344 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PREX1. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human PREX1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 57580 |
| Uniprot: | Q8TCU6 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | P-REX1, PREX1 |
| Background: |
| UniProt Protein Function: | PREX1: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Interacts preferentially with RAC2. Interacts with RAC1. Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, Rac/Rho Chromosomal Location of Human Ortholog: 20q13.13 Cellular Component: cytoplasm; cytosol; dendritic shaft; growth cone; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane Molecular Function:enzyme binding; GTPase activator activity; phospholipid binding; protein binding; Rho guanyl-nucleotide exchange factor activity Biological Process: actin filament polymerization; G-protein coupled receptor protein signaling pathway; neutrophil activation; neutrophil chemotaxis; positive regulation of GTPase activity; regulation of actin filament polymerization; regulation of dendrite development; regulation of Rho protein signal transduction; superoxide metabolic process; T cell differentiation |
| NCBI Summary: | The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TCU6 |
| NCBI GenInfo Identifier: | 148886999 |
| NCBI Gene ID: | 57580 |
| NCBI Accession: | Q8TCU6.3 |
| UniProt Secondary Accession: | Q8TCU6,Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55 Q9H4Q6, Q9P2D2, Q9UGQ4, E1P5X9, |
| UniProt Related Accession: | Q8TCU6 |
| Molecular Weight: | 175,847 Da |
| NCBI Full Name: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein |
| NCBI Synonym Full Names: | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 |
| NCBI Official Symbol: | PREX1Â Â |
| NCBI Official Synonym Symbols: | P-REX1Â Â |
| NCBI Protein Information: | phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein |
| UniProt Protein Name: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein |
| Protein Family: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein |
| UniProt Gene Name: | PREX1Â Â |
| UniProt Entry Name: | PREX1_HUMAN |
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